Association between Left Ventricular Dysfunction and Functional Outcomes at Three Months in Acute Ischemic Stroke

Area of Science:

• Cardiology
• Neurology
• Stroke Medicine

Background:

• Left ventricular dysfunction (LVD) is linked to stroke incidence and mortality.
• Limited research exists on LVD's effect on acute stroke functional outcomes.

Purpose of the Study:

• To investigate the association between left ventricular dysfunction (LVD) and functional outcomes in patients with acute ischemic stroke.
• To identify predictors of poor functional outcomes in stroke patients with LVD.

Main Methods:

• 1554 acute ischemic stroke patients were analyzed.
• Left ventricular ejection fraction (EF) determined LVD severity (severe ≤40%, mild 40-55%, normal ≥55%).
• Modified Rankin Scale (mRS) at 3 months assessed functional outcomes; multivariable analysis identified predictors.

Main Results:

• LVD was present in 137 patients (mild: 87, severe: 50).
• LVD patients were older, with more comorbidities (diabetes, atrial fibrillation, CAD), and severe stroke symptoms.
• LVD independently predicted poor functional outcomes at 3 months, alongside age, diabetes, NIHSS score, and stroke mechanism.

Conclusions:

• Left ventricular dysfunction is a significant independent predictor of poor functional outcomes in acute ischemic stroke.
• Early identification and management of LVD may improve stroke recovery.