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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

360
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Caregiver Perspectives on Polypharmacy Management in Children With Medical Complexity.

Pediatrics·2026
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Development of multicenter consensus care plans for immunosuppression after pediatric liver transplant: Reducing variability, creating comparative efficacy opportunities.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
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AASLD AST NASPGHAN Practice Guideline on pediatric liver transplantation: Post-transplant management.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
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Can Follow-up Liver Biopsies With Subsequent Protocolized Immunosuppression Intensification Reverse Long-term Rejection and Fibrosis After Pediatric Liver Transplantation?

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Meeting Report: The 2025 Annual Meeting of the Society of Pediatric Liver Transplantation.

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Living donor liver transplant is associated with lower hospitalization costs than deceased donor liver transplant: A multicenter cohort study of young children transplanted for biliary atresia.

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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
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Immunization practices among pediatric transplant hepatologists.

Amy G Feldman1, Allison Kempe2, Brenda L Beaty3

  • 1Digestive Health Institute, Children's Hospital Colorado, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.

Pediatric Transplantation
|July 25, 2016
PubMed
Summary

Pediatric liver transplant programs show varied vaccination practices, with many candidates and recipients under-immunized. Evidence-based protocols are needed to improve pediatric transplant immunization strategies.

Keywords:
immunizationslive vaccinesliver transplantationvaccinations

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Area of Science:

  • Pediatric Hepatology
  • Transplant Immunology
  • Vaccinology

Background:

  • Infectious complications are a major risk for pediatric liver transplant recipients.
  • Existing vaccine recommendations are often not followed, leading to under-immunization in this population.

Purpose of the Study:

  • To evaluate current pediatric liver transplant immunization practices.
  • To assess the role of infectious disease (ID) physicians in transplant evaluations.
  • To understand hepatologists' perceptions of vaccine safety and immunization barriers.

Main Methods:

  • An 80-item e-mail survey was distributed to pediatric transplant hepatologists in the US and Canada (SPLIT consortium).
  • Data were collected from December 2014 to March 2015.
  • Response rate was 80%, representing 97% of participating centers.

Main Results:

  • Only 50% of programs routinely involved an ID physician.
  • Palivizumab use varied (48% pre-transplant, 41% post-transplant).
  • Live vaccines were recommended by only 26% post-transplant, with some concern about transplant rejection (10%).

Conclusions:

  • Significant variation exists in pediatric liver transplant immunization practices.
  • Hepatologist involvement of ID physicians and vaccine administration protocols need improvement.
  • Development of evidence-based guidelines is crucial for optimizing vaccine uptake and safety in pediatric transplant recipients.