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qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
Published on: July 9, 2014
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Valvular Cytomegalovirus Endocarditis.
Timothy J Stear1, David Shersher2, George J Kim3
1Midwestern University, Downers Grove, Illinois.
The Annals of Thoracic Surgery
|July 25, 2016
Summary
Cytomegalovirus (CMV) endocarditis is rare. This case details a patient with human immunodeficiency virus who required valve replacement due to CMV infection of the heart valves.
Area of Science:
- Cardiology
- Infectious Diseases
- Virology
Background:
- Cytomegalovirus (CMV) infection is uncommon as a cause of endocarditis.
- The case involves a 49-year-old male with a history of human immunodeficiency virus (HIV), intravenous drug abuse, and chronic hepatitis B.
Observation:
- The patient presented with vegetations on the tricuspid and mitral valves.
- Despite antibiotic treatment, progressive valvular destruction necessitated surgical intervention.
Findings:
- The patient underwent successful replacement of the mitral and tricuspid valves.
- Pathological examination of the explanted valves revealed inclusion bodies characteristic of CMV.
- Quantitative serum polymerase chain reaction (PCR) confirmed a high CMV DNA load.
Implications:
- This case highlights CMV as a potential cause of severe valvular heart disease, particularly in immunocompromised individuals.
- Early recognition and diagnosis of CMV endocarditis are crucial for timely management.
- Further research into the pathogenesis and treatment of CMV endocarditis is warranted.
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