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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Reprogrammable microbial cell-based therapeutics against antibiotic-resistant bacteria.

In Young Hwang1, Elvin Koh2, Hye Rim Kim1

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Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|July 25, 2016
PubMed
Summary

Engineered bacteria offer a novel strategy against antibiotic resistance, addressing the decline in new antimicrobial drugs and the damage caused by broad-spectrum antibiotics to beneficial gut microbes.

Keywords:
Antibiotic-resistant pathogenBacteriocinMicrobiotaProphylactic agentSynthetic biology

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Area of Science:

  • Microbiology
  • Genetic Engineering
  • Pharmacology

Background:

  • Antimicrobial drugs have significantly reduced bacterial infection mortality for 60 years.
  • Indiscriminate antimicrobial use has led to multidrug-resistant bacteria, risking a return to the pre-antibiotic era.
  • Reduced antimicrobial drug discovery and collateral damage to commensal microbiota necessitate new therapeutic approaches.

Purpose of the Study:

  • To review recent advances in engineered bacteria as a novel antimicrobial strategy.
  • To explore the potential of reprogramming commensal bacteria for antimicrobial drug delivery.
  • To address the challenge of antibiotic resistance and the limitations of current therapies.

Main Methods:

  • Review of recent scientific literature on engineered bacteria and antibiotic resistance.
  • Discussion of genetic engineering techniques for modifying commensal bacteria.
  • Analysis of the efficacy and versatility of engineered bacteria against pathogens.

Main Results:

  • Genetic engineering allows for the reprogramming of commensal bacteria.
  • Engineered bacteria can be designed to deliver antimicrobial drugs with high efficacy.
  • This approach offers a versatile strategy against multidrug-resistant bacteria.

Conclusions:

  • Engineered bacteria represent a promising frontier in combating antibiotic resistance.
  • Reprogramming commensal microbiota offers a targeted and potentially less damaging alternative to broad-spectrum antibiotics.
  • Further research into engineered bacteria could revitalize antimicrobial therapy development.