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Related Experiment Video

Updated: Mar 17, 2026

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

A simple breath test for tuberculosis using ion mobility: A pilot study.

Amandip S Sahota¹, Ravi Gowda², Ramesh P Arasaradnam³

¹Dept. of Infection and Tropical Medicine, University Hospitals of Leicester NHS Trust, Infirmary Square, Leicester, LE1 5WW, UK.

Tuberculosis (Edinburgh, Scotland)

|July 25, 2016

Summary

This summary is machine-generated.

Breath analysis shows promise for diagnosing tuberculosis (TB). This study found an 81% sensitivity and 79% specificity in detecting TB through volatile organic compounds in breath samples.

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Last Updated: Mar 17, 2026

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

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Published on: April 9, 2012

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Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Published on: February 16, 2020

Area of Science:

Biomedical diagnostics
Analytical chemistry
Respiratory medicine

Background:

Tuberculosis (TB) remains a significant global health challenge, necessitating improved diagnostic methods.
Current diagnostic tools for TB can be costly, complex, or time-consuming.
Breath analysis offers a potential avenue for simpler, more robust, and cost-effective TB diagnosis.

Purpose of the Study:

To evaluate the efficacy of Ion Mobility Spectrometry (IMS) for diagnosing tuberculosis (TB) using breath analysis.
To determine the sensitivity and specificity of breath analysis in identifying patients with active TB.

Main Methods:

Breath samples were collected from 21 patients diagnosed with pulmonary or extra-pulmonary TB and 19 healthy controls.
TB diagnosis in patients was confirmed using standard reference tests (mycobacterial culture, histology, or radiology).
Chemical analysis of breath samples was performed using Ion Mobility Spectrometry (IMS).

Main Results:

The study achieved a sensitivity of 81% and a specificity of 79% for the detection of all TB cases (pulmonary and extra-pulmonary).
While sensitivity was lower than some studies focusing solely on pulmonary TB, the results indicate potential for breath analysis.
The specificity was calculated against interferon-gamma release assay negative controls.

Conclusions:

Breath analysis using IMS demonstrates potential as a diagnostic tool for tuberculosis.
Further refinement of sample collection methods may enhance the sensitivity of this diagnostic approach.
This non-invasive technique could contribute to more accessible TB diagnostics globally.