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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Developing Antitumor Magnetic Hyperthermia: Principles, Materials and Devices.

Alexander M Tishin, Alexander A Shtil, Alexander P Pyatakov

¹Faculty of Physics, M.V. Lomonosov Moscow State University, Leninskie Gory 1-2, Moscow 119991, Russian Federation. vi.zverev@physics.msu.ru.

Recent Patents on Anti-Cancer Drug Discovery

|July 25, 2016

Summary

This summary is machine-generated.

Magnetic hyperthermia uses magnetic nanoparticles and external magnetic fields to heat tumors, sparing healthy tissues. This targeted approach offers a promising strategy for treating difficult-to-manage cancers.

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Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Local anticancer treatments minimize systemic toxicity by targeting the disease site.
Hyperthermia, raising intratumoral temperature to 45°C, is explored for cancer therapy, alone or with radiation/chemotherapy.
External heat application risks damaging surrounding healthy tissues.

Purpose of the Study:

To review advances in magnetic hyperthermia for cancer treatment.
To explore novel nanoparticles with optimized properties for magnetic hyperthermia.
To focus on the development of therapeutic devices for magnetic hyperthermia.

Main Methods:

Utilizing exogenous nanosized particles within tumors.
Applying high-frequency magnetic or electromagnetic fields to induce localized heating.
Leveraging the energy transfer from external magnetic fields to nanoparticles for heat generation.

Main Results:

Analysis of physical principles governing magnetic hyperthermia.
Identification of novel nanoparticles with improved physico-chemical, toxicological, and tumoricidal characteristics.
Examination of device construction for therapeutic applications.

Conclusions:

Magnetic hyperthermia is an emerging approach for treating intractable malignancies.
Recent patents and literature highlight the progress in this field.
Targeted heating spares peritumoral non-malignant tissues, enhancing treatment safety.