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Melatonin and Human Cardiovascular Disease.

Seithikurippu R Pandi-Perumal1, Ahmed S BaHammam1, Nwakile I Ojike2

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|July 25, 2016
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Summary
This summary is machine-generated.

Melatonin may help treat coronary artery disorder (CAD) by lowering blood pressure and reducing platelet aggregation. Low melatonin levels are linked to cardiovascular issues, suggesting its therapeutic potential.

Keywords:
blood pressurecardioprotectioncardiovascular disorderscoronary artery diseasehypertensionmelatoninplatelets

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Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Pharmacology

Background:

  • Coronary artery disorder (CAD) pathophysiology is complex.
  • Melatonin's role in cardiovascular health is under investigation.
  • Low melatonin levels are observed in patients with CAD, hypertension, and heart failure.

Purpose of the Study:

  • To review the current literature on the cardiovascular effects of melatonin in humans.
  • To assess the potential therapeutic role of melatonin in coronary artery disorder.

Main Methods:

  • Literature review of studies on melatonin and cardiovascular parameters.
  • Analysis of human studies investigating melatonin's effects on blood pressure, platelet aggregation, and catecholamine levels.

Main Results:

  • Exogenous melatonin administration in humans has demonstrated benefits.
  • Observed effects include decreased nocturnal hypertension, improved blood pressure, reduced carotid artery pulsatility, decreased platelet aggregation, and lower serum catecholamine levels.

Conclusions:

  • Melatonin exhibits promising cardiovascular effects.
  • It warrants consideration in clinical trials for novel cardiovascular disorder therapies.
  • Further research into melatonin's therapeutic potential for cardiovascular diseases is recommended.