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Updated: Mar 17, 2026
Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
Published on: March 19, 2013
Genomic correction of familial cardiomyopathy in human engineered cardiac tissues
Francesca Stillitano1, Irene C Turnbull1, Ioannis Karakikes1,2
1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, PO Box 1030, New York, NY 10029, USA.
Abstract:
In this study, we used three-dimensional human engineered cardiac tissue technology to directly show that phospholamban (PLN) R14del mutation impairs cardiac contractility and to demonstrate restoration of contractile properties with targeted genetic correction of this inheritable form of dilated cardiomyopathy.
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