ECG-triggered high-pitch CT for simultaneous assessment of the aorta and coronary arteries
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Updated: Mar 17, 2026

Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
Published on: February 21, 2025
Anne-Lise Hachulla1, Maxime Ronot2, Stéphane Noble3
1Division of Radiology, University Hospitals of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva, Switzerland; Pulmonary Hypertension Program, University Hospitals of Geneva, Geneva, Switzerland.
Insights
High-pitch ECG-gated CT provides excellent image quality for both the aorta and coronary arteries. This method offers accurate diagnosis with limited radiation dose, even without beta-blockers.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Medical Diagnostics
Background:
- Computed tomography (CT) is crucial for cardiovascular assessment.
- Optimizing image quality and radiation dose in CT angiography remains a key challenge.
- ECG-gated CT techniques aim to improve visualization of dynamic cardiac structures.
Purpose of the Study:
- To evaluate the image quality of high-pitch ECG-gated CT for simultaneous imaging of the aorta and coronary arteries.
- To assess the diagnostic accuracy of this technique for detecting coronary artery stenosis.
- To determine the radiation dose associated with this imaging protocol.
Main Methods:
- Eighty-four patients underwent high-pitch ECG-gated CT without beta-blockers.
- Iterative reconstruction algorithms were employed.
- Contrast-to-noise ratio (CNR) was measured for the aorta and coronary arteries.
- Image quality was graded, and findings were compared with coronary angiography in a subset of patients.
Main Results:
- High-pitch acquisition yielded a mean dose-length product (DLP) of 234 ± 93 mGy·cm (4.2 mSv).
- Excellent image quality was achieved in 94% of patients for the aorta and 96% of coronary artery segments.
- The technique demonstrated high sensitivity (97%) and specificity (98%) for detecting significant coronary artery stenoses.
Conclusions:
- High-pitch ECG-gated CT enables accurate visualization of both the aorta and coronary arteries in a single acquisition.
- The method achieves this with limited radiation dose, even in patients with higher heart rates and without beta-blocker administration.
- Radiologists should consider reporting coronary artery disease findings during aortic CT examinations.
Objectives:
To study the image quality of ECG-gated-computed tomography (CT) acquisition with a high-pitch CT imaging for the exploration of both the aorta and coronary arteries.
Methods:
Eighty-four patients underwent high-pitch ECG-gated aortic CT without β-blockers with iterative reconstruction algorithms. Contrast-to-noise ratio (CNR) between vessels and adjacent perivascular fat tissue were calculated on the aorta and the coronary arteries. Dose-length-products (DLP) were recorded. Two blinded readers graded image quality of the aorta and the coronary arteries on a 3-point scale. Coronary artery stenoses were compared with coronary angiograms in 24 patients. Kappa values were calculated.
Results:
High-pitch acquisition resulted in a mean DLP of 234 ± 93 mGy cm(4.2 mSv) for an acquisition of the entire aorta, (mean 73 ± 16 bpm). CNR for ascending aorta was 10.6 ± 4 and CNR for coronary arteries was 9.85 ± 4.1. Image quality was excellent in 79/84 patients (94%), and excellent or moderate but diagnostic in 1087/1127 coronary artery segments (96%). 74 significant stenoses were observed, and 38/40 significant stenoses were confirmed by coronary angiography (K = 0.91, Sensitivity = 0.97, Specificity = 0.98).
Conclusion:
High-pitch ECG-gated aortic CT with iterative reconstructions allows an accurate exploration of both aorta and coronary arteries during the same acquisition, with limited dose deposition, despite the lack of β-blockers and relatively high heart rate. Radiologists need to be aware of the necessity to analyze and report coronary artery disease in aortic examination.
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