Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.3K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.3K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

2.3K
2.3K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

9.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
9.1K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

1.7K
1.7K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Estimating Reaction Rate Constants from Impedance Spectra: Combining Microkinetic Modeling and Experiments of the Oxygen Evolution Reaction.

The journal of physical chemistry. C, Nanomaterials and interfaces·2026
Same author

Long-Range Transverse-Momentum Correlations and Radial Flow in Pb-Pb Collisions at the LHC.

Physical review letters·2026
Same author

Advancing neural interfaces: a framework for the fabrication and characterization of freestanding micro-nanodevices.

Microsystems & nanoengineering·2026
Same author

Search for Quasiparticle Scattering in the Quark-Gluon Plasma with Jet Splittings in pp and Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2025
Same author

First Measurement of A=4 Hypernuclei and Antihypernuclei at the LHC.

Physical review letters·2025
Same author

Experimental realization of a helical magnetic structure at Ni/Gd interfaces at room temperature.

Physical chemistry chemical physics : PCCP·2025

Related Experiment Video

Updated: Mar 17, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.3K

Evolving Strategies for Therapeutically Targeting Cancer Stem Cells.

S Talukdar1, L Emdad2, S K Das2

  • 1Virginia Commonwealth University, School of Medicine, Richmond, VA, United States.

Advances in Cancer Research
|July 25, 2016
PubMed
Summary
This summary is machine-generated.

Cancer stem cells (CSCs) drive tumor growth and recurrence due to their self-renewal and resistance to therapy. Targeting CSCs offers a promising strategy to improve cancer treatment outcomes and prevent metastasis.

Keywords:
CSC markersCancer stem cellsHeterogeneityPotential targetsTherapy resistance

More Related Videos

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.7K
Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples
09:57

Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples

Published on: May 10, 2017

8.1K

Related Experiment Videos

Last Updated: Mar 17, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

20.3K
Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
09:25

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

19.7K
Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples
09:57

Harnessing the DNA Dye-triggered Side Population Phenotype to Detect and Purify Cancer Stem Cells from Biological Samples

Published on: May 10, 2017

8.1K

Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Cancer is a complex disease influenced by genetic, epigenetic, and microenvironmental factors.
  • Cancer stem cells (CSCs) are a critical subpopulation responsible for tumor initiation, growth, and relapse.
  • CSCs possess unique properties like self-renewal, plasticity, and resistance to conventional therapies, contributing to poor prognosis.

Purpose of the Study:

  • To review the multifaceted role of cancer stem cells (CSCs) in cancer development and progression.
  • To highlight the therapeutic challenges posed by CSCs, including their resistance to treatment and contribution to metastasis.
  • To explore current and emerging strategies for targeting CSCs in cancer therapy.

Main Methods:

  • Review of existing literature on cancer stem cells, tumor microenvironment, and therapeutic resistance.
  • Analysis of clinical trial data for CSC-targeting therapies.
  • Identification of novel CSC targets and therapeutic approaches.

Main Results:

  • CSCs are key drivers of tumor heterogeneity, metastasis, and therapeutic resistance.
  • CSCs exhibit plasticity influenced by the tumor microenvironment, complicating treatment strategies.
  • Several CSC-targeting therapies, including combination therapies and immunotherapies, are in clinical trials.

Conclusions:

  • Targeting cancer stem cells is crucial for overcoming therapeutic resistance and preventing cancer recurrence and metastasis.
  • Emerging strategies like epigenetic modifiers, stemness inhibitors, and novel drug targets show significant potential.
  • Further research into CSC biology and targeted therapies is essential for advancing cancer treatment.