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Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques

Tao Chen1, Yan Chen2, Cinzia Stella2

  • 1Small Molecule Pharmaceutical Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, United States.

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
|July 25, 2016
PubMed

Keywords:
AggregationsAntibody drug conjugate (ADC)Charge variantsCritical quality attribute (CQA)Drug distributionDrug-to-antibody ratio (DAR)Free drug analysisPeptide mapping

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