Ultra-low-dose chest CT with iterative reconstruction does not alter anatomical image quality

To evaluate the effect of dose reduction with iterative reconstruction (IR) on image quality of chest CT scan.

Eighteen human cadavers had chest CT with one reference CT protocol (RP-CT; 120kVp/200mAs) and two protocols with dose reduction: low-dose-CT (LD-CT; 120kVp/40mAs) and ultra-low-dose CT (ULD-CT; 120kVp/10mAs). Data were reconstructed with filter-back-projection (FBP) for RP-CT and with FBP and IR (sinogram affirmed iterative reconstruction [SAFIRE^®]) algorithm for LD-CT and ULD-CT. Volume CT dose index (CTDIvol) were recorded. The signal-to-noise (SNR), contrast-to-noise (CNR) ratios of LD-CT and ULD-CT and quantitative parameters were compared to RP-CT. Two radiologists reviewed the CT examinations assessed independently the quality of anatomical structures and expressed a confidence level using a 2-point scale (50% and 95%).

CTDIvol was 2.69 mGy for LD-CT (-80%; P<0.01) and 0.67 mGy for ULD-CT (-95%; P<0.01) as compared to 13.42 mGy for RP-CT. SNR and CNR were significantly decreased (P<0.01) for LD-CT and ULD-CT, but IR improved these values satisfactorily. No significant differences were observed for quantitative measurements. Radiologists rated excellent/good the RP-CT and LD-CT images, whereas good/fair the ULD-CT images. Confidence level for subjective anatomical analysis was 95% for all protocols.

Dose reduction with a dose lower than 1 mGy, used in conjunction with IR allows performing chest CT examinations that provide a high quality of anatomical structures.