Topical peptides as cosmeceuticals

Area of Science:

• Dermatology and Cosmetology
• Biochemistry
• Molecular Biology

Background:

• Peptides are crucial signaling molecules in physiological processes like immunity and homeostasis.
• Synthetic peptides are now utilized in dermatology and cosmetology for skin benefits.
• Their evolution spans from antibiotics to advanced cosmeceuticals.

Purpose of the Study:

• To review the roles and applications of peptides in cosmeceuticals.
• To explore the mechanisms of action for cosmeceutical peptides.
• To assess the advantages and disadvantages of peptide use in skincare.

Main Methods:

• Literature review of peptide functions and applications in dermatology.
• Analysis of peptide mechanisms as signal modulators, structural components, carriers, and neurotransmitter modulators.
• Evaluation of transdermal delivery enhancement strategies.

Main Results:

• Cosmeceutical peptides target extracellular matrix synthesis, pigmentation, immunity, and inflammation.
• Delivery can be improved using enhancers, chemical modification, or encapsulation.
• Advantages include physiological relevance, selectivity, and low immunogenicity.

Conclusions:

• Peptides offer significant potential in cosmeceuticals due to their diverse skin functions.
• Challenges include weak clinical evidence, poor absorption, and high cost.
• Optimizing delivery and validating efficacy are key for future development.