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Estradiol-tethered micropatterned surfaces for the study of estrogenic non-genomic pathways
1Faculté de Pharmacie and Département de Chimie, Université de Montréal, CP 6128 Succursale Center Ville, Montréal, QC H3C 3J7, Canada. francoise.winnik@umontreal.ca.
Chemical Communications (Cambridge, England)
|July 26, 2016
Abstract:
Besides its well-known hormonal effects initiated in the nucleus, estradiol (E2) also activates non-nuclear pathways through interactions with receptors located on the cell plasma membrane. Micropatterned substrates consisting of gold dots bearing tethered E2 distributed on a cell-adhesive substrate were prepared and shown to trigger specifically E2 non-genomic effects in cells grown on the substrates.
