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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Pregnancy testing.

C A Horwitz1, C V Lee1

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|July 26, 2016
PubMed
Summary
This summary is machine-generated.

Immunoassays, including radioimmunoassay, are now standard for pregnancy detection, largely replacing older bioassays. Their sensitivity makes them ideal for diagnosing early and ectopic pregnancies.

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Area of Science:

  • Clinical Chemistry
  • Biotechnology
  • Reproductive Medicine

Background:

  • Bioassays were historically used for pregnancy detection.
  • Immunoassays have become the predominant method.
  • Various immunoassay formats exist for clinical use.

Purpose of the Study:

  • To review the role of immunoassays in pregnancy detection.
  • To highlight the advantages of immunoassays over bioassays.
  • To discuss the specific applications of radioimmunoassay.

Main Methods:

  • Review of clinical diagnostic techniques.
  • Comparison of immunoassay and bioassay performance.
  • Evaluation of radioimmunoassay sensitivity and specificity.

Main Results:

  • Immunoassays have largely superseded bioassays for pregnancy testing.
  • Slide and tube immunoassays are suitable for general clinical use.
  • Radioimmunoassay offers high sensitivity for early and ectopic pregnancy diagnosis.

Conclusions:

  • Immunoassays represent a significant advancement in pregnancy diagnostics.
  • Radioimmunoassay is particularly valuable for complex early pregnancy cases.
  • Current immunoassay technologies provide reliable and sensitive pregnancy detection.