Penetration of enoxacin into lung tissue

For a study of penetration of enoxacin into lung, patients undergoing pneumonectomy were given 400 mg by mouth the night before and again approx 2 h before operation. A blood sample was taken as the lung was excised. Lung and serum enoxacin concentrations were assayed by high pressure liquid chromatography. Results from 15 patients showed that enoxacin was concentrated in the lung. Enoxacin lung concentrations were 3.2-13.1 mg/l, and ratios of lung to serum concentrations were 3-6 (mean, 4.2).