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Published on: January 26, 2024
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Risk factors for cardiopulmonary dysfunction in early-onset severe pre-eclampsia
Fei Guan1, Jing Ye1, Jianhua Lin1
1Department of Obstetrics and Gynecology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Summary
Early-onset severe pre-eclampsia patients with renal insufficiency and ascites face cardiopulmonary dysfunction. Ascites requires close monitoring during expectant management for better outcomes.
Area of Science:
- Obstetrics and Gynecology
- Cardiology
- Nephrology
Background:
- Early-onset severe pre-eclampsia poses significant risks to maternal cardiopulmonary function.
- Expectant management is a common approach, but patient characteristics influencing outcomes require further investigation.
Purpose of the Study:
- To identify patient characteristics associated with cardiopulmonary function in early-onset severe pre-eclampsia under expectant management.
- To understand predictors of cardiopulmonary decompensation in this high-risk obstetric population.
Main Methods:
- Retrospective study of 93 patients with early-onset severe pre-eclampsia managed expectantly.
- Patients categorized into decompensatory and normal cardiopulmonary function groups.
- Clinical characteristics compared using binary logistic regression and Student t-test.
Main Results:
- Serum creatinine, ascites, and increased proteinuria were significantly associated with cardiopulmonary decompensation (P=0.017, P=0.001, P=0.015, respectively).
- Hypoproteinemia increased the odds of ascites (OR 3.16; 95% CI 1.34-7.44).
- Patients without ascites had higher mean serum albumin levels (P<0.001).
Conclusions:
- Renal insufficiency and the presence of ascites are linked to cardiopulmonary dysfunction in early-onset severe pre-eclampsia.
- Ascites warrants increased medical attention during expectant management for this condition.
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