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Zinc Levels in Left Ventricular Hypertrophy
Lei Huang1, Tianming Teng1, Bo Bian1
1Department of Cardiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, 300052, China.
Biological Trace Element Research
|July 26, 2016
Summary
Low serum zinc levels are linked to left ventricular hypertrophy (LVH) in patients. This study found lower zinc in LVH patients, particularly those with eccentric or concentric LVH, indicating a significant inverse relationship with left ventricular mass.
Area of Science:
- Cardiology
- Trace Element Metabolism
Background:
- Zinc homeostasis is crucial for cellular function and structure.
- Zinc dysregulation is associated with various diseases, including cardiovascular conditions.
- Left ventricular hypertrophy (LVH) is a significant cardiac condition with potential links to trace element imbalances.
Purpose of the Study:
- To investigate the relationship between serum zinc levels and left ventricular hypertrophy (LVH).
- To analyze associations between zinc levels and different left ventricular (LV) geometry patterns.
- To determine correlations between zinc and specific LV mass and remodeling parameters.
Main Methods:
- Serum zinc levels were measured in 519 patients.
- Patients were categorized based on LV geometry: normal, concentric remodeling, eccentric LVH, and concentric LVH.
- Linear and multiple regression analyses were used to assess relationships with left ventricular mass (LVM), left ventricular mass index (LVMI), and relative wall thickness (RWT).
Main Results:
- Serum zinc levels were lower in LVH patients (641.9 ± 215.2 μg/L) compared to controls (710.2 ± 243.0 μg/L).
- A significant inverse linear relationship was observed between zinc levels and LVM (p=0.001) and LVMI (p=0.000).
- No significant relationship was found between zinc levels and RWT (p=0.561).
Conclusions:
- Serum zinc levels are significantly decreased in patients with LVH, especially eccentric and concentric types.
- A significant inverse correlation exists between serum zinc levels and LVM and LVMI.
- These findings suggest a potential role for zinc in the pathophysiology of LVH.
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