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Updated: Mar 17, 2026
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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
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Sublingual Immunotherapy for the Polyallergic Patient.
Amber N Pepper1, Moisés A Calderón2, Thomas B Casale1
1Division of Allergy and Immunology, Department of Internal Medicine, University of South Florida Morsani College of Medicine and James A. Haley Veterans' Affairs Hospital, Tampa, Fla.
Summary
Sublingual immunotherapy (SLIT) is a key treatment for allergies. This review focuses on using SLIT for polyallergic patients in the United States, highlighting treatment variations.
Area of Science:
- Allergy and Immunology
- Immunotherapy
Background:
- Allergen immunotherapy is the sole disease-modifying treatment for allergic conditions.
- Sublingual immunotherapy (SLIT) has been utilized in Europe and recently gained FDA approval in the US for allergic rhinitis.
Purpose of the Study:
- To review the application of SLIT in the United States.
- To focus on the treatment of polyallergic patients using SLIT.
Main Methods:
- Review of current literature and clinical practices regarding SLIT.
- Distinguishing between polysensitization and polyallergy in patient assessment.
Main Results:
- SLIT tablets were approved by the FDA in 2014 for allergic rhinitis.
- Treatment strategies for polysensitized patients differ between the US and Europe, particularly concerning polyallergy.
Conclusions:
- SLIT is an emerging treatment option in the US for allergic diseases.
- Understanding the distinction between polysensitization and polyallergy is crucial for effective SLIT treatment in the US.
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