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Modeling Breast Cancer via an Intraductal Injection of Cre-expressing Adenovirus into the Mouse Mammary Gland
Published on: June 7, 2019
[Discussion of breast cancer screening model in China]
1Project Office(Li WQ), Department of Utralsonography(Li R), Tianjin Women's and Children's Health Center, Tianjin 300070, China; Department of Breast Imaging(Liu PF), Department of Epidemiology and Biostatistics(Huang YB), Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, China.
Abstract:
Cancer screening has been considered as double-edged sword with both advantages and disadvantages. For decades, there have been strong interests in screening strategies for the early detection of cancers to reduce the mortality, especially breast X-ray(mammography)screening. However, several evidences also suggested that the benefit of reduction of breast-cancer mortality with mammography might become a problem due to the repeat mammography, subsequent biopsies, and overdiagnosis. And different screening strategies with different models, different intervals, and different target populations also incurred debates. After systematical analysis and discussion, we suggested to focus on high-risk population, improve the accuracy of screening technique, conduct the informed consent of participants, and explore individual screening mode in the screening of breast cancer.
