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Routine Hemostasis and Hemogram Parameters: Valuable Assessments for Coagulation Disorder and Chemotherapy in Cancer
Ying-Wei Zhu1, Tong-Bao Feng2, Xian-Ju Zhou3
1Department of Oncology, Changzhou Second People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, Jiangsu 213164, China.
Chinese Medical Journal
|July 26, 2016
Summary
Cancer patients often experience clotting abnormalities. Routine tests like D-dimer (DD) and complete blood count (CBC) can assess thrombosis risk and monitor treatment effectiveness, aiding prognosis.
Area of Science:
- Hematology
- Oncology
- Clinical Pathology
Background:
- Clotting system abnormalities are frequent complications in cancer patients.
- Evaluating coagulation status, clinical features, and treatment is crucial for managing these patients.
Purpose of the Study:
- To retrospectively evaluate coagulation state, clinical features, and treatment in cancer patients using routine tests.
- To assess the utility of D-dimer (DD) and complete blood count (CBC) in identifying thrombosis risk and monitoring chemotherapy.
Main Methods:
- Retrospective analysis of 2328 cancer patients, classified into D-dimer (DD) positive (n=1419) and negative (n=909) groups.
- Hemostasis tests and CBC performed on patients undergoing chemotherapy or follow-up.
- Analysis of factors influencing hypercoagulable state and correlation with clinical parameters.
Main Results:
- Hypercoagulable state correlated with clinical staging and metastasis site (P < 0.0001).
- Higher fibrinogen, prolonged aPTT, and PT interacted with clinical stage in the DD-positive group (P < 0.05).
- Hypercoagulable plasma profile moderated 2-3 weeks post-chemotherapy (P < 0.05).
Conclusions:
- Routine hemostatic parameters and CBC are valuable for assessing thrombosis risk in cancer patients.
- These tests aid in monitoring chemotherapy effectiveness and predicting disease prognosis.
- D-dimer levels, while indicative of hypercoagulability, showed no correlation with WBC, RBC, or platelet count in the positive DD group.
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