Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.8K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zebrafish behavioral assessment as a first-tier whole-organism NAM for developmental neurotoxicity: A multi-laboratory evaluation.

Neurotoxicology·2026
Same author

Integrated Chemical and Toxicity Screening of Tap Drinking Water across Western Oregon Using Suspect and Nontarget Screening.

Environmental science & technology·2026
Same author

Corrigendum to "Chemical structure drives developmental toxicity of alkyl-substituted naphthalenes in zebrafish" [Environ. Int. 204 (2025) 109837].

Environment international·2026
Same author

Morphological, Behavioral, and Transcriptomic Profiling Reveals Developmental Toxicity of PCB Metabolites in Zebrafish.

Toxics·2026
Same author

FINS: An interactive platform for automated zebrafish image analysis and morphological screening.

SLAS technology·2026
Same author

Discovery of INCB191358: A Potent and Selective DGKα/ζ Dual Inhibitor.

Journal of medicinal chemistry·2026

Related Experiment Video

Updated: Mar 17, 2026

A 3-dimensional 3D-printed Template for High Throughput Zebrafish Embryo Arraying
04:52

A 3-dimensional 3D-printed Template for High Throughput Zebrafish Embryo Arraying

Published on: June 1, 2018

7.5K

Optimizing multi-dimensional high throughput screening using zebrafish.

Lisa Truong1, Sean M Bugel1, Anna Chlebowski1

  • 1Department of Environmental and Molecular Toxicology, The Sinnhuber Aquatic Research Laboratory, and the Environmental Health Sciences Center at Oregon State University, Corvallis, OR, USA.

Reproductive Toxicology (Elmsford, N.Y.)
|July 26, 2016
PubMed
Summary
This summary is machine-generated.

Digital dispensing improves zebrafish high throughput screening (HTS) for chemical bioactivity, enhancing data quality and reproducibility in drug discovery and toxicology. Implementing these best practices is crucial for reliable results.

Keywords:
Developmental toxicityHigh throughput screeningZebrafish

More Related Videos

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

18.3K
Development of automated imaging and analysis for zebrafish chemical screens.
10:49

Development of automated imaging and analysis for zebrafish chemical screens.

Published on: June 24, 2010

11.9K

Related Experiment Videos

Last Updated: Mar 17, 2026

A 3-dimensional 3D-printed Template for High Throughput Zebrafish Embryo Arraying
04:52

A 3-dimensional 3D-printed Template for High Throughput Zebrafish Embryo Arraying

Published on: June 1, 2018

7.5K
A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

18.3K
Development of automated imaging and analysis for zebrafish chemical screens.
10:49

Development of automated imaging and analysis for zebrafish chemical screens.

Published on: June 24, 2010

11.9K

Area of Science:

  • Pharmacology
  • Toxicology
  • Genomics

Background:

  • Zebrafish are increasingly used for high throughput screening (HTS) in drug discovery and toxicology.
  • Standardized protocols are needed to ensure data reliability in zebrafish HTS.

Purpose of the Study:

  • To compare chemical delivery methods for zebrafish HTS.
  • To identify best practices for improving data quality and reproducibility.

Main Methods:

  • Comparison of digital dispensing versus plastic tip-based liquid handling.
  • Assessment of chemical concentration, sorption, and biological responses (transcription, whole animal).

Main Results:

  • Digital dispensing provides higher data quality and reproducibility than standard liquid handling.
  • Challenges exist with trace impurities in test chemicals affecting sensitive zebrafish models.

Conclusions:

  • Adopting digital dispensing and addressing chemical purity are key for robust zebrafish HTS.
  • Improved practices will enhance cross-laboratory reproducibility in chemical bioactivity assessments.