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Related Experiment Video

Updated: Mar 17, 2026

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

High-Throughput Microfluidic Device for Circulating Tumor Cell Isolation from Whole Blood.

Daniel K Yang¹, Serena Leong², Lydia L Sohn¹

¹Dept. of Mechanical Engineering, University of California, Berkeley, CA 94720 USA.

Micro Total Analysis Systems : Proceedings of the ... [Mu] TAS International Conference on Miniaturized Chemical and Biochemical Analysis Systems. [Mu] TAS (Conference)

|July 26, 2016

Summary

This summary is machine-generated.

We developed a microfluidic device to isolate circulating tumor cells (CTCs) from blood. This technology shows high recovery rates, aiding cancer patient prognosis and therapy tracking.

Keywords:

CTC Inertial microfluidics Size-based separation

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Last Updated: Mar 17, 2026

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples

Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood Samples

Published on: June 15, 2012

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Clinical Microfluidic Chip Platform for the Isolation of Versatile Circulating Tumor Cells

Published on: October 13, 2023

Area of Science:

Biomedical Engineering
Oncology
Microfluidics

Background:

Circulating tumor cells (CTCs) are crucial biomarkers for cancer prognosis and monitoring treatment efficacy.
Accurate isolation of CTCs from whole blood is essential for clinical applications.

Purpose of the Study:

To develop and validate a novel microfluidic device for efficient CTC isolation.
To assess the device's performance in recovering cancer cells from whole blood.

Main Methods:

A multi-stage microfluidic device was designed utilizing inertial and Dean drag forces.
The device was tested using whole blood samples spiked with MCF-7 GFP cancer cells.

Main Results:

The microfluidic device achieved a high recovery rate of 94.2% ± 2.1% for cancer cells.
Demonstrated effective isolation of CTCs from complex blood matrices.

Conclusions:

The developed microfluidic device offers a promising tool for CTC isolation.
This technology can enhance the clinical utility of CTCs for cancer patient management.