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A Software App for Radiotherapy with In-situ Dose-painting using high Z nanoparticles.

M Jermoumi1, A Yucel2, Y Hao2

  • 1Department of Physics and Applied Physics, Medical Physics Program, University of Massachusetts Lowell, MA USA; Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.

IFMBE Proceedings
|July 26, 2016
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Summary

This study introduces the Radiotherapy with In-situ Dose-painting (RAID) application, a free software tool for modeling dose enhancement using high-Z nanoparticles (HZNPs). It simulates nanoparticle biodistribution and dose boosts for various radiotherapy sources.

Keywords:
Dose paintingdose enhancementhigh atomic number nanoparticles

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Area of Science:

  • Medical Physics
  • Radiotherapy
  • Nanotechnology

Background:

  • Radiotherapy planning requires accurate dose calculation.
  • High-Z nanoparticles (HZNPs) offer potential for enhancing radiation dose in tumors.
  • Simulating nanoparticle behavior and dose enhancement is complex.

Purpose of the Study:

  • To develop user-friendly, free software for modeling Radiotherapy with In-situ Dose-painting (RAID).
  • To simulate intra-tumor HZNPs biodistribution and dose enhancement.
  • To support research in nanoparticle-based radiotherapy.

Main Methods:

  • Developed a deterministic code in Matlab for simulation.
  • Created a Graphical User Interface (GUI) for user interaction.
  • Modeled dose enhancement from I-125, Pd-102, Cs-131, and kilovoltage x-rays.

Main Results:

  • The RAID application simulates space-time biodistribution of HZNPs.
  • Calculates dose enhancement within tumor sub-volumes.
  • Provides parameters for dose enhancement and NP biodistribution.

Conclusions:

  • The RAID APP is a valuable research tool for dose-painting radiotherapy.
  • It facilitates the study of HZNPs for targeted dose enhancement.
  • Potential for future development in treatment planning with radiosensitizers.