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Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids

Affordable Oxygen Microscopy-Assisted Biofabrication of Multicellular Spheroids

Published on: April 6, 2022

Oxygen Delivering Biomaterials for Tissue Engineering.

Ashley L Farris¹, Alexandra N Rindone¹, Warren L Grayson²

¹Translational TE Center, Johns Hopkins University School of Medicine, Baltimore MD 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore MD, 21205 USA.

Journal of Materials Chemistry. B

|July 26, 2016

Summary

This summary is machine-generated.

Oxygen delivery remains a key challenge in tissue engineering (TE). This review covers technologies to improve oxygen supply for TE scaffolds and their clinical translation potential.

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Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures

Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures

Published on: January 6, 2010

Area of Science:

Biomedical Engineering
Regenerative Medicine
Cell Biology

Background:

Tissue engineering (TE) offers regenerative strategies but faces clinical translation barriers.
Limited oxygen diffusion in TE scaffolds hinders cell survival and function.
Oxygen acts as a crucial signaling molecule for stem cell differentiation in TE.

Purpose of the Study:

To review current technologies for enhancing oxygen supply in TE scaffolds.
To discuss the mechanisms and in vivo applications of these oxygen delivery strategies.
To explore emerging technologies and future prospects for oxygen delivery in TE.

Main Methods:

Overview of existing oxygen delivery technologies for TE.
Analysis of underlying mechanisms of oxygen transport and utilization.
Review of in vivo applications and clinical translation progress.

Main Results:

Various technologies exist to improve oxygen supply, including hyperbaric oxygen, oxygen carriers, and oxygen-generating materials.
These technologies address oxygen diffusion limitations and support stem cell differentiation.
Significant progress has been made, but challenges remain for widespread clinical application.

Conclusions:

Optimizing oxygen delivery is critical for advancing TE towards clinical success.
Continued development of novel oxygenation strategies is essential.
Bridging the gap between TE research and clinical application requires addressing oxygen supply challenges.