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Updated: Mar 17, 2026
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
Discovery of prostate specific antigen pattern to predict castration resistant prostate cancer of androgen
Yejin Kim1, Yong Hyun Park2, Ji Youl Lee2
1Department of Creative IT Engineering, POSTECH, Pohang, South Korea.
Background:
Prostate specific antigen (PSA) is an important biomarker to monitor the response to the treatment, but has not been fully utilized as a whole sequence. We used a longitudinal biomarker PSA to discover a new prognostic pattern that predicts castration-resistant prostate cancer (CRPC) after androgen deprivation therapy.
Methods:
We transformed the longitudinal PSA into a discrete sequence, used frequent sequential pattern mining to find candidate patterns from the sequences, and selected the most predictive and informative pattern among the candidates.
Results:
Patients were less likely to be CRPC if, after PSA values reach nadir, the PSA decreases more than 0.048 ng/ml during a month, and the decrease occurs again. This pattern significantly increased the accuracy of predicting CRPC by supplementing information provided by existing PSA patterns such as pretreatment PSA.
Conclusions:
This result can help clinicians to stratify men by the risk of CRPC and to determine the patient that needs intensive follow-up.
