Discovery of prostate specific antigen pattern to predict castration resistant prostate cancer of androgen deprivation therapy
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Updated: Mar 17, 2026
Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
Yejin Kim1, Yong Hyun Park2, Ji Youl Lee2
1Department of Creative IT Engineering, POSTECH, Pohang, South Korea.
Background:
Prostate specific antigen (PSA) is an important biomarker to monitor the response to the treatment, but has not been fully utilized as a whole sequence. We used a longitudinal biomarker PSA to discover a new prognostic pattern that predicts castration-resistant prostate cancer (CRPC) after androgen deprivation therapy.
Methods:
We transformed the longitudinal PSA into a discrete sequence, used frequent sequential pattern mining to find candidate patterns from the sequences, and selected the most predictive and informative pattern among the candidates.
Results:
Patients were less likely to be CRPC if, after PSA values reach nadir, the PSA decreases more than 0.048 ng/ml during a month, and the decrease occurs again. This pattern significantly increased the accuracy of predicting CRPC by supplementing information provided by existing PSA patterns such as pretreatment PSA.
Conclusions:
This result can help clinicians to stratify men by the risk of CRPC and to determine the patient that needs intensive follow-up.
