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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Effect of cholesterol lowering treatment on plasma markers of endothelial dysfunction in chronic kidney disease

Angelo Zinellu1, Salvatore Sotgia1, Arduino A Mangoni2

  • 1Department of Biomedical Sciences - University of Sassari, Sassari, Italy.

Journal of Pharmaceutical and Biomedical Analysis
|July 26, 2016
PubMed

Insights

Cholesterol-lowering treatments significantly reduced asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD) patients. This improvement in endothelial dysfunction markers may be linked to reduced oxidative stress and inflammation.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Chronic kidney disease (CKD) is associated with high cardiovascular risk, driven by endothelial dysfunction.
  • This dysfunction stems from a pro-inflammatory and pro-oxidative state characteristic of CKD.

Purpose of the Study:

  • To investigate the impact of cholesterol-lowering therapies on endothelial dysfunction markers in CKD patients.
  • Specifically examining asymmetric dimethylarginine (ADMA), vascular cell adhesion molecule (VCAM), and intercellular adhesion molecule (ICAM).

Main Methods:

  • 30 CKD patients were randomized into three cholesterol-lowering treatment groups for 12 months.
  • Measurements included plasma ADMA, Kynurenine/Tryptophan (Kyn/Trp) ratio, malondialdehyde (MDA), allantoin/uric acid (All/UA) ratio, VCAM, and ICAM.
  • Treatments: simvastatin 40mg/day, ezetimibe/simvastatin 10/20mg/day, or ezetimibe/simvastatin 10/40mg/day.

Main Results:

  • Cholesterol-lowering treatment significantly reduced plasma ADMA concentrations across all groups.
  • A parallel significant decrease was observed in oxidative stress markers (MDA, All/UA ratio) and inflammation marker (Kyn/Trp ratio).
  • No significant changes were noted in VCAM and ICAM plasma concentrations.

Conclusions:

  • Cholesterol-lowering treatment effectively reduces ADMA levels in CKD patients, indicating improved endothelial function.
  • The observed benefits may be mediated by a reduction in systemic oxidative stress and inflammation.
  • Further research could explore the long-term cardiovascular implications.

Keywords:
Asymmetric dimethylarginineChronic kidney diseaseEzetimibeIntercellular adhesion moleculeOxidative stressSimvastatinVascular cell adhesion molecule

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