Search research articles

Search research articles

Related Experiment Video

Updated: Mar 17, 2026

Engineered Vascularized Muscle Flap

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

Preliminary Exploration: When Angiosome Meets Prefabricated Flaps.

Heng Xu¹, Zheng Zhang¹, Yimeng Xia²

¹Department of Plastic Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal of Reconstructive Microsurgery

|July 26, 2016

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The genetic architecture of pain intensity in a sample of 598,339 U.S. veterans.

medRxiv : the preprint server for health sciences·2023

Same author

Resistance mechanisms of immune checkpoint inhibition in lymphoma: Focusing on the tumor microenvironment.

Frontiers in pharmacology·2023

Same author

circNEIL3 inhibits tumor metastasis through recruiting the E3 ubiquitin ligase Nedd4L to degrade YBX1.

Proceedings of the National Academy of Sciences of the United States of America·2023

Same author

Integrated biochemical and transcriptomic analysis reveals the effects of Burkholderia sp. SRB-1 on cadmium accumulating in Chrysopogon zizanioides L. under Cd stress.

Journal of environmental management·2023

Same author

Characterization of immature ovarian teratomas through single-cell transcriptome.

Frontiers in immunology·2023

Same author

Phenotypic Heterogeneity Analysis of APC-Mutant Colon Cancer by Proteomics and Phosphoproteomics Identifies RAI14 as a Key Prognostic Determinant in East Asians and Westerners.

Molecular & cellular proteomics : MCP·2023

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Angiosomes can limit blood flow in prefabricated flaps, but new blood vessels can overcome this. This study in rats shows cross-bound neovascularization improves flap survival by bypassing these limitations.

Area of Science:

Plastic Surgery
Regenerative Medicine
Vascular Biology

Background:

Prefabricated flaps have limited survival areas, potentially due to insufficient neovascularization.
The innate vascular network of flaps and the concept of angiosomes may create conflicting theories on blood perfusion.
This study investigates the role of angiosomes in prefabricated flap survival.

Purpose of the Study:

To determine if angiosomes impede blood perfusion in prefabricated flaps.
To investigate the impact of neovascularization time and pedicle orientation on flap survival.
To elucidate the mechanisms of blood supply in prefabricated flaps.

Main Methods:

A two-stage operation of a prefabricated abdominal flap was performed in a rat model.

More Related Videos

A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies

A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies

Published on: March 31, 2022

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

Related Experiment Videos

Last Updated: Mar 17, 2026

Engineered Vascularized Muscle Flap

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies

A Reliable Porcine Fascio-Cutaneous Flap Model for Vascularized Composite Allografts Bioengineering Studies

Published on: March 31, 2022

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Fabrication of Engineered Vascular Flaps Using 3D Printing Technologies

Published on: May 19, 2022

Rats were divided into five groups with varying pedicle angles and prefabrication times (2-3 weeks).

Macroscopic appearance, near-infrared fluorescence imaging, and capillary density were analyzed.

Main Results:

No significant difference in survival area between horizontal and oblique pedicle angles (Groups A & B).
Vertical pedicle angle (Group C) showed significantly smaller survival area than the horizontal pedicle in the same position (Group D).
Angiosome boundaries limited perfusion in some groups, while cross-bound neovascularization in Groups A & D improved it. Capillary density correlated positively with neovascularization time.

Conclusions:

Angiosomes act as a barrier to blood perfusion in prefabricated flaps.
Cross-bound neovascular vessels are crucial for nourishing prefabricated flaps and overcoming angiosome limitations.
Optimizing neovascularization strategies can enhance prefabricated flap survival.