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Updated: Mar 17, 2026
Retrospective Cardiac Gating with A Prototype Small-Animal X-ray Computed Tomograph
Published on: February 21, 2025
Ventricular-arterial coupling assessment using gated single-photon emission computed tomography: relationship with
Osvaldo H Masoli1, Marcela Redruello, Lucas San Miguel
1Department of Cardiovascular Imaging, TCBA, Buenos Aires, Argentina.
Aims:
In patients with normal myocardial perfusion, ST-segment depression and reserve pulse pressure (rPP) can identify patients at higher risk of cardiovascular events. We aimed to explore the prevalence of impaired ventricular-arterial coupling (VAc) in patients with normal myocardial perfusion imaging and its relationship with ST-segment depression and rPP.
Methods And Results:
The present study included consecutive patients with normal myocardial perfusion imaging by single-photon emission computed tomography and ST-segment depression. Stroke volume, end-systolic pressure, arterial elastance (Ea), ventricular elastance (Ev), and VAc (Ea/Ev) were estimated both at rest and during stress. The difference between stress and rest (ΔVAc) was calculated. A positive ΔVAc was considered an impaired ΔVAc (iVAc).
Results:
A total of 92 patients were prospectively included. iVAc was identified in 44 (59%) patients with ST-segment depression compared with 3 (16%) patients with normal repolarization (P=0.001). A higher incidence of abnormal rPP was identified in patients with ST-segment depression compared with the control group (61 vs. 16%, P=0.0001). ST-segment depression was identified as the only independent predictor of iVAc (adjusted OR 7.5; 95% CI 1.9-30.0, P=0.004).
Conclusion:
Noninvasive assessment of VAc is feasible with gated single-photon emission computed tomography and appears to be related to ST-segment depression and reserve rPP.
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