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Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR
Keunhong Jeong1,2, Chawita Netirojjanakul1,2, Henrik K Munch1,2
1Department of Chemistry, University of California , Berkeley, California 94720-1460, United States.
Abstract:
We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.
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