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Updated: Mar 17, 2026
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
[Application of chromosomal microarray analysis for a cohort of Chinese patients with spontaneous miscarriage]
Haiming Yuan1, Mengfan Chen, Xiaoyan Deng
1Guangzhou Kingmed Center for Clinical Laboratory, Guangzhou, Guangdong 510330, China.
Objective:
To explore the relationship between spontaneous miscarriage and chromosomal aberrations identifiable with chromosomal microarray analysis (CMA).
Methods:
A total of 440 product-of-conceptions were collected for the CMA testing.
Results:
Four hundred and seventeen of 440 specimens (94.7%) were successfully detected, among which 209 (50.1%) were chromosomal abnormalities. One hundred and twenty-nine (61.7%) of the 209 specimens were numerical chromosomal abnormalities, 40 specimens (19.1%) were structural anomalies, 38 specimens (18.1%) were mosaicisms, and 2 specimens (1.0%) showed regions of homozygosity.
Conclusion:
CMA analysis of products of-conception specimens can yield a higher diagnostic rate than conventional karyotyping. The identification of the cause of spontaneous miscarriage can facilitate estimation of recurrence risks for future pregnancies.
