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Published on: July 22, 2012
A cluster of Enterovirus 71 subgenogroup C2 in a nursery school, Italy, 2014
Maria Cristina Medici1, Fabio Tummolo1, Maria Cristina Arcangeletti1
1Unit of Microbiology and Virology, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
Insights
Enterovirus 71 (EV71) subgenogroup C2 was detected in Italian children with mild illness. This finding identified a new EV71 lineage spreading in Europe, with implications for public health surveillance.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Enteroviruses are a significant cause of febrile and neurological illness in children.
- Enterovirus 71 (EV71) is a notable pathogen, particularly its C2 subgenogroup.
Observation:
- In October 2014, EV RNA was identified in four children hospitalized with mild febrile and vomiting illness in Parma, Italy.
- The detected viruses were confirmed as EV71 subgenogroup C2 through sequencing.
Findings:
- Phylogenetic analysis revealed a distinct lineage within EV71 subgenogroup C2, encompassing the Italian strains and those previously found in France in 2013.
- This represents the first documented outbreak of EV71 C2 in Italy.
Implications:
- The identification of this outbreak expands knowledge of EV71 C2's geographic spread and clinical significance in Europe.
- This highlights the need for continued molecular surveillance of enteroviruses across European regions.
Abstract:
During October 2014, enterovirus (EV) RNA was detected in the stools of four children attending the same class in a nursery school, and hospitalized with mild febrile and vomiting disease in Parma, Italy. Upon sequencing, the viruses were characterized as EV71 subgenogroup C2. Phylogenetic analysis of the four EV71 C2 viruses allowed the distinction of a diverging lineage within subgenogroup C2, containing the Italian EV71 C2 strains and viruses detected in France in 2013. The identification of an outbreak of EV71 C2 in Italy extended information on the geographic diffusion and clinical relevance of these viruses in Europe.
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