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Published on: June 10, 2025
Nutritional Deficiency in Patients with Heart Failure
Edoardo Sciatti1, Carlo Lombardi2, Alice Ravera3
1Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedali Civili 1, Brescia 25123, Italy. edoardo.sc@tin.it.
Micronutrient deficiencies are common in heart failure (HF), impacting quality of life and outcomes. This review examines their role and the limited evidence on micronutrient supplementation efficacy in HF patients.
Area of Science:
- Cardiology
- Nutritional Science
- Internal Medicine
Background:
- Heart failure (HF) is a leading cause of death and illness in Western nations, with significant healthcare costs.
- Despite advances, HF prognosis remains poor, and poor dietary habits negatively affect patient quality of life and outcomes.
- Current HF guidelines lack specific nutritional strategies, highlighting a gap in patient management.
Purpose of the Study:
- To review the current understanding of nutritional deficiencies in heart failure patients.
- To analyze the physiological roles and prognostic significance of various micronutrients in HF.
- To evaluate the existing evidence on the efficacy of micronutrient supplementation for improving HF outcomes.
Main Methods:
- Systematic literature review of studies on nutritional status in heart failure.
- Analysis of physiological mechanisms linking micronutrient deficiencies to HF pathophysiology.
- Evaluation of clinical trial data and observational studies on micronutrient supplementation in HF.
Main Results:
- Micronutrient deficiencies are prevalent in heart failure populations.
- Specific deficiencies are linked to HF severity, symptoms, and adverse events.
- Evidence supporting routine micronutrient supplementation in HF is limited and lacks robust clinical trial data.
Conclusions:
- Nutritional deficiencies represent a significant, yet often overlooked, aspect of heart failure management.
- Further research, particularly large randomized trials, is needed to establish the role and efficacy of micronutrient supplementation in HF.
- Personalized nutritional assessment and targeted supplementation may be beneficial, but require more evidence.
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