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Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation.

Yizhou Dong1, Weiheng Wang2,3, Omid Veiseh2,4,3

  • 1Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy, The Ohio State University , Columbus, Ohio 43210, United States.

Langmuir : the ACS Journal of Surfaces and Colloids
|July 26, 2016
PubMed
Summary

Researchers developed a new injectable hydrogel that responds to glucose levels. This self-healing material, formed via boronic acid-glucose complexation, shows promise for drug delivery applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Injectable hydrogels are crucial for various biomedical applications.
  • Developing smart hydrogels with tunable properties remains an active research area.
  • Glucose-responsive materials offer precise control for targeted therapies.

Purpose of the Study:

  • To create a novel injectable hydrogel system.
  • To achieve glucose-responsiveness through boronic acid-glucose complexation.
  • To evaluate the hydrogel's properties for potential drug delivery.

Main Methods:

  • Synthesized polymers with varying percentages of boronic acid and glucose functional groups.
  • Investigated the critical ratio of functional groups for hydrogel formation.
  • Characterized the hydrogel's injectability, shear-thinning, and self-healing properties.
  • Assessed the glucose-responsive release of an encapsulated model drug.

Main Results:

  • Hydrogel formation was optimized with 10-60% boronic acid functional groups.
  • The hydrogels exhibited shear-thinning and rapid self-healing capabilities.
  • Demonstrated controlled, glucose-responsive drug release from the hydrogel matrix.
  • The system relies on a single-component polymeric material for complexation.

Conclusions:

  • A novel injectable and glucose-responsive hydrogel was successfully developed.
  • The boronic acid-glucose complexation strategy provides a robust method for hydrogel formation.
  • The material's properties make it a promising candidate for advanced drug delivery systems.