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The prevalence of cardiovascular disease in non-communicating hydrocephalus

Per Kristian Eide1, Are Hugo Pripp2

  • 1Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway.

Clinical Neurology and Neurosurgery
|July 26, 2016
PubMed

Insights

Cardiovascular disease is more common in patients with non-communicating hydrocephalus (HC). This suggests a link between cardiovascular issues and the development of non-communicating HC, with diabetes also associated with abnormal intracranial pressure.

Area of Science:

  • Neurology
  • Cardiology
  • Epidemiology

Background:

  • Non-communicating hydrocephalus (HC) results from blocked cerebrospinal fluid (CSF) pathways.
  • The relationship between cardiovascular disease (CVD) prevalence in non-communicating HC patients and the general population is not well-established.

Purpose of the Study:

  • To compare the prevalence of CVD in non-communicating HC patients versus a general population control group.
  • To investigate CVD prevalence in non-communicating HC patients compared to communicating hydrocephalus (idiopathic normal pressure hydrocephalus, iNPH) patients.

Main Methods:

  • Retrospective analysis of 50 non-communicating HC cases.
  • Comparison with a general control population (HUNT3 Survey, n=35,413) and iNPH patients (n=176).
  • Assessment of CVD prevalence including arterial hypertension, angina pectoris, cardiac infarction, and diabetes.

Main Results:

  • Increased prevalence of arterial hypertension (males), cardiac infarction (females), and diabetes (females) in non-communicating HC patients compared to the HUNT3 cohort.
  • No significant difference in overall CVD prevalence between non-communicating HC and iNPH patients.
  • Elevated diabetes prevalence in both non-communicating HC and iNPH patients with abnormal pulsatile intracranial pressure (ICP).

Conclusions:

  • A significantly higher prevalence of CVD exists in non-communicating HC, suggesting an association with its development.
  • Diabetes is linked to abnormal pulsatile ICP in both non-communicating HC and iNPH.
  • Findings indicate a potential shared pathophysiology or risk factors between CVD and non-communicating HC.
Abstract

Keywords:
Cardiovascular diseaseHUNT 3 surveyIdiopathic normal pressure hydrocephalusNon-communicating hydrocephalusPrevalence

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