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[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].

V I Pilipenko, D A Teplyuk, A K Shakhovskaya

    Voprosy Pitaniia
    |July 27, 2016
    PubMed
    Summary
    This summary is machine-generated.

    A new functional drink improved irritable bowel syndrome with constipation (IBS-C) symptoms like pain and bloating, and boosted quality of life. However, heartburn was a notable side effect requiring formulation adjustments.

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    Area of Science:

    • Gastroenterology
    • Nutritional Science
    • Functional Foods

    Background:

    • Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder significantly impacting quality of life and incurring high social costs.
    • Dietary interventions are a key therapeutic strategy for IBS management.
    • Developing and evaluating innovative functional foods for IBS patients is an active area of research.

    Purpose of the Study:

    • To clinically evaluate an instant drink containing inulin, menthol, and pyridoxine as a potential therapeutic option for IBS with constipation (IBS-C).

    Main Methods:

    • A randomized controlled trial involving 49 IBS-C patients (Rome III criteria) aged 18-68 years.
    • Participants received either the functional drink (4g inulin, 4mg menthol, 2mg pyridoxine daily) plus standard diet or a standard diet alone for 2 weeks.
    • Symptom severity (pain, bloating, incomplete emptying), stool frequency, Bristol stool scale, and quality of life (IBSQoL) were assessed daily and pre/post-treatment.

    Main Results:

    • The functional drink group showed significant improvements in stool frequency (p=0.05) and Bristol stool scale index (p=0.05).
    • Abdominal pain, bloating, and incomplete bowel emptying severity were significantly reduced (p<0.05 for all).
    • Quality of life scores increased significantly (p=0.05), but 10 out of 25 patients reported heartburn as an adverse effect.

    Conclusions:

    • The functional drink containing inulin, menthol, and pyridoxine demonstrates efficacy in improving stool parameters, reducing abdominal pain and bloating, and enhancing quality of life in IBS-C patients.
    • The observed heartburn suggests a need for modifications in the functional drink's composition to mitigate adverse effects.