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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Updated: Mar 17, 2026

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
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[Zinc and gastrointestinal disorders].

Yasuki Higashimura, Tomohisa Takagi, Yuji Naito

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |July 27, 2016
    PubMed
    Summary

    Zinc deficiency impacts numerous bodily functions and increases disease risk. This study explores zinc

    Area of Science:

    • Nutrition Science
    • Gastroenterology
    • Biochemistry

    Background:

    • Zinc is an essential trace element vital for immune function, metabolism, and sensory perception.
    • Zinc deficiency affects approximately 20% of the Japanese population and poses a risk for over 25% globally.
    • Deficiency symptoms include immunodeficiency and impaired taste, increasing susceptibility to various diseases.

    Purpose of the Study:

    • To investigate the therapeutic effects of zinc on gastrointestinal disorders.
    • To highlight zinc's role in healing mucosal and epithelial damage within the GI tract.

    Main Methods:

    • Review of existing literature on zinc's role in gastrointestinal health.
    • Examination of clinical applications, such as the use of polaprezinc for gastric ulcers and gastritis.

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    Main Results:

    • Zinc is crucial for the repair of mucosal and epithelial damage in the gastrointestinal system.
    • Compounds like polaprezinc demonstrate efficacy in treating gastric conditions.

    Conclusions:

    • Zinc plays a significant therapeutic role in managing gastrointestinal disorders.
    • Further research into zinc supplementation and its applications in gastroenterology is warranted.