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[Zinc and type 2 diabetes].

Ayako Fukunaka, Yoshio Fujitani

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |July 27, 2016
    PubMed
    Summary

    Zinc is crucial for regulating glucose metabolism, especially in pancreatic beta cells. This review explores how zinc transporters impact diabetes, highlighting their emerging role in the disease.

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Cell Biology

    Background:

    • Pancreatic beta cells have the highest zinc concentration in the body.
    • Zinc's role in diabetes is of significant interest, though mechanisms remain unclear.
    • Zinc deficiency is linked to diabetes, but precise regulatory pathways are not fully understood.

    Purpose of the Study:

    • To review the role of zinc in glucose metabolism.
    • To focus on the emerging role of zinc transporters in diabetes.

    Main Methods:

    • Literature review of studies on zinc, metabolism, and diabetes.
    • Analysis of research on zinc transporters and their function.
    • Synthesis of current understanding of zinc's impact on glucose regulation.

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    Main Results:

    • Zinc signaling is mediated by specific zinc transporters in a tissue-specific manner.
    • Defects in certain zinc transporters can lead to human diseases.
    • Emerging evidence points to zinc transporters as key players in diabetes.

    Conclusions:

    • Zinc transporters are critical for zinc homeostasis and cellular function.
    • Understanding zinc transporter mechanisms is vital for unraveling diabetes pathogenesis.
    • Targeting zinc transporters may offer novel therapeutic strategies for diabetes.