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Updated: Mar 17, 2026

Author Spotlight: Assessing the Impact of Novel Iron Chelators on Cancer Cell Metabolism
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[Iron function and carcinogenesis].

Shinya Akatsuka, Shinya Toyokuni

    Nihon Rinsho. Japanese Journal of Clinical Medicine
    |July 27, 2016
    PubMed
    Summary

    Excess iron, vital for bodily functions, can paradoxically promote cancer (oncogenesis) by generating reactive oxygen. This review explores the link between iron and cancer, including animal models of iron-related carcinogenesis.

    Area of Science:

    • Biochemistry
    • Oncology
    • Toxicology

    Background:

    • Iron is an essential micronutrient crucial for oxygen transport and electron transport.
    • Iron overload is linked to increased cancer risk, notably hepatocellular carcinoma in hereditary hemochromatosis.
    • Certain asbestos types with higher iron content are more carcinogenic, suggesting a role in mesothelioma.

    Purpose of the Study:

    • To outline the general relationship between iron and cancer (oncogenesis).
    • To explain iron-related animal models of carcinogenesis.
    • To highlight the dual role of iron as essential and potentially dangerous.

    Main Methods:

    • Literature review on iron's role in cancer.
    • Analysis of epidemiological data linking iron overload to specific cancers.

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  • Review of established animal models for iron-induced carcinogenesis.

    • Main Results:

    • Excess iron catalyzes the generation of reactive oxygen species, contributing to cellular damage and oncogenesis.
    • Specific conditions like hereditary hemochromatosis demonstrate a clear link between iron overload and liver cancer.
    • Iron content in carcinogens like asbestos correlates with their carcinogenic potential.

    Conclusions:

    • While essential, iron's dysregulation can promote cancer development.
    • Understanding iron's role is critical for cancer prevention and treatment strategies.
    • Iron-related animal models provide valuable insights into cancer mechanisms.