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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Updated: Mar 17, 2026

Experimental Protocol for Detecting Cyanobacteria in Liquid and Solid Samples with an Antibody Microarray Chip

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The Use of Biochip Array Technology for Rapid Multimycotoxin Screening.

Monika Plotan¹, Raymond Devlin¹, Jonathan Porter¹

¹Randox Food Diagnostics, 55 Diamond Rd, Crumlin, County Antrim, BT29 4QY, United Kingdom.

Journal of AOAC International

|July 27, 2016

Summary

This summary is machine-generated.

This study introduces a cost-effective biochip array technology for rapid, semiquantitative screening of multiple mycotoxins in feed. The validated method ensures feed safety compliance with European standards.

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Area of Science:

Food safety analysis
Analytical chemistry
Immunotechnology

Background:

Mycotoxins (aflatoxins, fumonisins, ochratoxins, trichothecenes, zearalenones) pose significant risks to human and animal health.
European regulations set limits for mycotoxins in feed, necessitating reliable detection methods.

Purpose of the Study:

To develop and validate a biochip array technology for semiquantitative multimycotoxin screening in feed.
To verify compliance of feed materials with safety standards using a novel analytical tool.

Main Methods:

Application of simultaneous competitive chemiluminescent immunoassays on the Evidence Investigator analyzer.
Development and validation based on European Commission Decision No. 2002/657/EC.
Utilized a single generic sample-preparation method for broad mycotoxin detection.

Main Results:

Achieved low coefficients of variation (CVs) for repeatability (10.6%) and within-laboratory reproducibility (11.6%).
Demonstrated high sensitivity with low decision limits and detection capabilities due to minimal matrix effects.
Showed excellent correlation with assigned values in FAPAS proficiency testing and authentic feed samples analyzed by LC-MS/MS.

Conclusions:

The validated biochip array technology is a reliable, innovative, cost-effective, and multianalytical tool for mycotoxin screening in feed.
This method facilitates efficient verification of feed material compliance with safety standards.