Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Peptide Identification Using Tandem Mass Spectrometry

Peptide Identification Using Tandem Mass Spectrometry

Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeting oxidative stress pathways in epilepsy: mechanistic insights into the role of ascorbic acid.

Molecular biology reports·2026

Same author

pH-induced structural switch of a parallel duplex to triplex-DNA at a BOLF1 gene segment of the human herpes virus 4 (HH4) genome.

Bioorganic & medicinal chemistry·2026

Same author

Stability of G/C DNA Tetraplexes at Physiological pH Formed at the Promoter-UTR Intersection of the <i>RAP2C</i> Gene: Structural Multitude of a G/C Rich Genomic Segment.

ACS omega·2025

Same author

Multiformity of a G/C Rich Segment at the Promoter-UTR Intersection of <i>RAP2C</i> Gene: Structural Validation by Circular Dichroism.

ACS omega·2025

Same author

Probing into 9'-substituted Suzuki-coupled noscapine ionic liquids as potent microtubule targeting anticancer agents with hemoglobin affinity.

Scientific reports·2025

Same author

Decoding the relationship between oxidative stress and antiseizure medications using network pharmacology and molecular docking.

Scientific reports·2025

Search research articles

Related Experiment Video

Updated: Mar 17, 2026

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

Peptide Biomarkers: Exploring the Diagnostic Aspect.

Swati Mahendru¹, Kapil Roy¹, Shrikant Kukreti²

¹Nucleic Acids Research Laboratory, Department of Chemistry, University of Delhi (North Campus), Delhi 110007, India.

Current Protein & Peptide Science

|July 27, 2016

Summary

Peptides show promise as diagnostic biomarkers due to their stability and ability to reflect disease changes. Research highlights techniques like peptidomics for discovering these valuable peptide biomarkers.

Keywords:

Diagnostic peptides imaging biomarkers non-imaging biomarkers peptide microarray peptide modification peptidomics

More Related Videos

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

Related Experiment Videos

Last Updated: Mar 17, 2026

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Detection of Human Leukocyte Antigen Biomarkers in Breast Cancer Utilizing Label-free Biosensor Technology

Published on: March 24, 2015

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Low Molecular Weight Protein Enrichment on Mesoporous Silica Thin Films for Biomarker Discovery

Published on: April 17, 2012

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Author Spotlight: Engineering Molecular Tools for Disease Detection and Imaging

Published on: December 8, 2023

Area of Science:

Biomarker Discovery
Proteomics
Diagnostic Technologies

Background:

Accurate diagnostic methods are crucial for managing the rise in deadly diseases.
There is a need for specific and sensitive biomarkers to enhance diagnosis and guide targeted therapies.

Purpose of the Study:

To evaluate the significance of peptides as diagnostic tools.
To review techniques for discovering peptide biomarkers.

Main Methods:

Structured literature search of bibliographic databases.
Evaluation of peer-reviewed research on peptide biomarkers and their discovery.

Main Results:

Peptide biomarkers are classified based on diagnostic approaches.
Techniques such as peptidomics and peptide microarrays are employed for peptide biomarker discovery.

Conclusions:

Peptides are promising biomarkers due to their small size, stability, and low immunogenicity.
Their ability to mirror pathological changes makes them valuable for disease detection and monitoring.