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Published on: August 25, 2014
Developmental Outcomes of Late Preterm Infants From Infancy to Kindergarten
Prachi Shah1, Niko Kaciroti2, Blair Richards2
1Division of Developmental Behavioral Pediatrics, Department of Pediatrics, School of Medicine, Center for Human Growth and Development, and prachis@umich.edu.
Insights
Late preterm infants show developmental delays in early infancy and later in preschool and kindergarten reading, though outcomes are comparable at 24 months. Continued monitoring of late preterm infants is recommended.
Area of Science:
- Developmental pediatrics
- Neonatal research
- Child psychology
Background:
- Late preterm infants (34-36 weeks' gestation) may face developmental challenges compared to early term (37-38 weeks) and full term (39-41 weeks) infants.
- Understanding long-term developmental trajectories is crucial for this population.
Purpose of the Study:
- To compare developmental outcomes of late preterm infants with early term and full-term infants from infancy through kindergarten.
- To identify potential developmental disparities in specific domains and timepoints.
Main Methods:
- Utilized data from the Early Childhood Longitudinal Study, Birth Cohort, including 1000 late preterm, 1800 early term, and 3200 term infants.
- Assessed development at 9 and 24 months using Bayley Scales and at preschool/kindergarten using ECLS-B reading and math scores.
- Employed multilinear regression to compare outcomes between groups, controlling for covariates.
Main Results:
- Late preterm infants had significantly lower developmental scores at 9 months compared to early term and term infants (P < .0001).
- No significant differences were observed at 24 months (P = .66).
- Late preterm infants showed poorer performance in preschool reading (P = .0006), preschool math (P = .0014), and kindergarten reading (P = .0007) compared to term infants.
Conclusions:
- Late preterm infants' developmental outcomes are comparable to full-term infants at 24 months but lag in reading at preschool and kindergarten.
- Ongoing developmental surveillance is essential for late preterm infants through their early school years.
Objective:
To compare developmental outcomes of late preterm infants (34-36 weeks' gestation) with infants born at early term (37-38 weeks' gestation) and term (39-41 weeks' gestation), from infancy through kindergarten.
Methods:
Sample included 1000 late preterm, 1800 early term, and 3200 term infants ascertained from the Early Childhood Longitudinal Study, Birth Cohort. Direct assessments of development were performed at 9 and 24 months by using the Bayley Short Form-Research Edition T-scores and at preschool and kindergarten using the Early Childhood Longitudinal Study, Birth Cohort reading and mathematics θ scores. Maternal and infant characteristics were obtained from birth certificate data and parent questionnaires. After controlling for covariates, we compared mean developmental outcomes between late preterm and full-term groups in serial cross-sectional analyses at each timepoint using multilinear regression, with pairwise comparisons testing for group differences by gestational age categories.
Results:
With covariates controlled at all timepoints, at 9 months late preterm infants demonstrated less optimal developmental outcomes (T = 47.31) compared with infants born early term (T = 49.12) and term (T = 50.09) (P < .0001). This association was not seen at 24 months, (P = .66) but reemerged at preschool. Late preterm infants demonstrated less optimal scores in preschool reading (P = .0006), preschool mathematics (P = .0014), and kindergarten reading (P = .0007) compared with infants born at term gestation.
Conclusions:
Although late preterm infants demonstrate comparable developmental outcomes to full-term infants (early term and full-term gestation) at 24 months, they demonstrate less optimal reading outcomes at preschool and kindergarten timepoints. Ongoing developmental surveillance for late preterm infants is warranted into preschool and kindergarten.
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