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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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The Reed-Sternberg Cell, An Activated T-cell? The Evidence Has Come Full Circle.

M E Kadin1

  • 1a Department of Pathology, Harvard Medical School and Beth Israel Hospital, Boston, Massachusetts, USA.

Leukemia & Lymphoma
|July 27, 2016
PubMed
Summary
This summary is machine-generated.

The origin of malignant Reed-Sternberg (RS) cells in Hodgkin

Keywords:
Hodgkin's diseaseReed-Sternberg cellsT-cell antigens

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • The cellular origin of malignant Reed-Sternberg (RS) cells in Hodgkin's disease (HD) remains a complex and debated topic in hematopathology.
  • Previous in vitro studies investigating T-cell characteristics of RS cells yielded inconclusive results.

Purpose of the Study:

  • To elucidate the cellular lineage and origin of Reed-Sternberg cells in various histologic types of Hodgkin's disease.
  • To explore the implications of RS cell characteristics for understanding HD pathology and etiology.

Main Methods:

  • Utilizing advanced immunohistochemical techniques to detect lineage-specific antigens on RS cells.
  • Analyzing antigen expression patterns across different histological subtypes of Hodgkin's disease.

Main Results:

  • Reed-Sternberg cells express T-lineage antigens in a significant proportion (25-60%) of Hodgkin's disease cases, excluding nodular lymphocyte predominance HD.
  • All investigated RS cells demonstrated expression of lymphocyte activation antigens, irrespective of lineage.

Conclusions:

  • These findings suggest a T-cell origin for RS cells in a subset of Hodgkin's disease, while nodular lymphocyte predominance HD appears to be a B-cell disorder.
  • Understanding RS cell characteristics, including T-cell lineage association and activation markers, is crucial for advancing the comprehension of HD's histopathology, clinical presentation, and underlying causes.