Related Experiment Video
Updated: Mar 17, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
Polyclonal Bence Jones Proteinuria Associated with Reactive Plasmacytosis
S W Tarlton1, S Ariad2, D Lewis1
1a South African Institute for Medical Research, and University of the Witwatersrand.
This study reports a rare case of a patient with respiratory symptoms and enlarged lymph nodes, showing polytypic plasma cells in blood tests. The findings suggest a potential link to Epstein-Barr virus in B cell proliferation.
Area of Science:
- Hematology
- Oncology
- Infectious Diseases
Background:
- A 43-year-old male presented with acute respiratory symptoms, fever, malaise, and epistaxis.
- Physical examination indicated generalized lymphadenopathy and hepatosplenomegaly.
- Peripheral blood analysis revealed significant plasmacytosis.
Purpose of the Study:
- To investigate the underlying cause of plasmacytosis and Bence Jones proteinuria in this patient.
- To explore the potential role of Epstein-Barr virus (EBV) in B cell proliferation.
Main Methods:
- Peripheral blood examination for plasmacytosis.
- Analysis of Bence Jones proteinuria for kappa and lambda light chains.
- Serum electrophoresis to detect monoclonal peaks.
- Cytoplasmic immunoglobulin and gene rearrangement studies on peripheral blood plasma cells.
Main Results:
- Bence Jones proteinuria with both kappa and lambda light chains was detected.
- No monoclonal peak was observed on serum electrophoresis.
- Plasma cell studies demonstrated polyclonality, not monoclonality.
Conclusions:
- The patient's presentation, despite plasmacytosis and Bence Jones proteinuria, did not fit typical multiple myeloma criteria due to polyclonality.
- The study discusses the potential involvement of Epstein-Barr virus in driving B cell proliferation in this unique case.
More Related Videos
10:15Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
07:38Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
Published on: May 6, 2018
Related Concept Videos
Nephrotic Syndrome II : Assessment and Medical Management
Nephrotic Syndrome I : Introduction
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Acute Pyelonephritis II: Diagnostic Studies and Management
Acute Pyelonephritis I: Introduction
Serum Studies: Renal Function Tests