Foxp3 overexpression in tumor cells predicts poor survival in oral squamous cell carcinoma
Jing-Jing Song1, Si-Jia Zhao2, Juan Fang1
1Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Oral Diseases, Sun Yat-sen University, No. 56, Lingyuan West Road, Guangzhou, 510055, China.
Background:
Forkhead Box P3 (Foxp3) is a regulatory T cells marker, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of Foxp3 expression with clinicopathological parameters and prognosis in oral squamous cell carcinoma (OSCC).
Methods:
Foxp3 expression was examined using immunohistochemistry (IHC) in paraffin-embedded tissue samples from 273 OSCC patients. Statistical analysis was performed to evaluate the associations between Foxp3 expression, the clinicopathologic characteristics and prognostic factors in OSCC.
Results:
Foxp3 protein expression was significantly associated with lymph node metastasis (P <0.01). Both univariate and multivariate analyses revealed that Foxp3 was an independent factor for both 5 years overall survival (OS) and relapse-free survival (RFS) (both P <0.01). Patients with Foxp3 overexpression had shorter OS and RFS.
Conclusions:
Our results determined that elevated Foxp3 protein expression was a predictive factor of outcome in OSCC and could act as a promising therapeutic target.
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