Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Imaging of sub-surface defect in CFRP laminate using A<sub>0</sub>-mode Lamb wave: Analytical, numerical and experimental studies.

Ultrasonics·2022

Same author

Design of microfluidic channels to prevent negative filtration in implantable hemofiltration devices.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2021

Same author

Effect of oxaliplatin-based chemotherapy on chemosensitivity in patients with peritoneal metastasis from colorectal cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: proof-of-concept study.

BJS open·2021

Same author

Downstaging of lymph node metastasis after neoadjuvant intraperitoneal and systemic chemotherapy in gastric carcinoma with peritoneal metastasis.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2019

Same author

Expression Pattern of Mitochondrial ND2 Gene in Human Leukemia and in HL60 Cells During Growth and Differentiation.

Leukemia & lymphoma·2016

Same author

Suppression of phase transitions at low temperature by chromium substitution in vanadium spinel Fe(V1-x Cr x )2O4.

Journal of physics. Condensed matter : an Institute of Physics journal·2016

Same journal

Glofitamab for the treatment of relapsed/refractory hairy cell leukemia: a case report.

Leukemia & lymphoma·2026

Same journal

Pre- and post-transplant serum albumin levels and outcomes after allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia.

Leukemia & lymphoma·2026

Same journal

Leukemia mortality analysis in the pediatric population in São Paulo state, Brazil, 2000-2019.

Leukemia & lymphoma·2026

Same journal

CPX‑351 vs. FLAG‑ida in patients with high-risk AML/MDS and MDS-related gene mutations: a subgroup analysis of the UK NCRI AML19 trial.

Leukemia & lymphoma·2026

Same journal

Specialist palliative care access and end-of-life hospitalizations in acute leukemia: a nationwide register study.

Leukemia & lymphoma·2026

Same journal

D-VRD vs. D-KRD induction in transplant-eligible multiple myeloma: a real-world comparison.

Leukemia & lymphoma·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 17, 2026

Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia

Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia

Published on: June 9, 2023

Thymosin β4 Gene Expression in Leukemic Cells.

J Kudo¹, R Shimamura¹, H Ishibashi¹

¹a From the First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, 812, Japan.

Leukemia & Lymphoma

|July 27, 2016

Summary

This summary is machine-generated.

Thymosin β4 (Tβ4), a ubiquitous peptide, is explored for its gene expression in leukemic cells. Its precise function remains elusive, but its role in cell growth and differentiation is under investigation.

Keywords:

Thymosin β4 differentiation gene expression leukemia

More Related Videos

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Related Experiment Videos

Last Updated: Mar 17, 2026

Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia

Co-Culture and Transduction of Murine Thymocytes on Delta-Like 4-Expressing Stromal Cells to Study Oncogenes in T-Cell Leukemia

Published on: June 9, 2023

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia

Published on: September 18, 2013

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

Area of Science:

Molecular Biology
Cell Biology
Biochemistry

Background:

Thymosin β4 (Tβ4) was initially identified as a thymic hormone with immune and endocrine functions.
Tβ4 is a conserved peptide found across mammalian and vertebrate tissues.
Tβ4 lacks a signal peptide, suggesting it is not a secretory protein.

Purpose of the Study:

To review the molecular biology of Thymosin β4 (Tβ4).
To focus on Tβ4 gene expression in leukemic cells and cell lines.
To investigate Tβ4's role during cellular growth and differentiation.

Main Methods:

Molecular cloning and sequence analysis of Tβ4 cDNA.
Analysis of Tβ4 gene expression patterns.
Review of existing literature on Tβ4 functions.

Main Results:

Tβ4 is ubiquitously expressed in mammalian tissues.
Tβ4 gene expression analysis in leukemic cell lines is a key focus.
The exact biological function of Tβ4 is still under investigation.

Conclusions:

Thymosin β4 (Tβ4) is a non-secretory peptide with a widespread presence.
Further research into Tβ4 gene expression is crucial for understanding its role in leukemia.
The function of Tβ4 in cellular processes like growth and differentiation requires continued study.