Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acral localized acquired cutis laxa.

B K Fisher1, E Page, W Hanna

  • 1Division of Dermatology, Wellesley Hospital, Toronto, Ontario, Canada.

Journal of the American Academy of Dermatology
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomarkers of psychological stress are associated with increased susceptibility to the development of breast and prostate cancer in BRCA1/2 mutation carriers.

British journal of cancer·2025
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

Author Correction: A dense ring of the trans-Neptunian object Quaoar outside its Roche limit.

Nature·2024
Same author

A dense ring of the trans-Neptunian object Quaoar outside its Roche limit.

Nature·2023
Same author

Canadian Surgery Forum 2018: St. John's, NL Sept. 13-15, 2018.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Society, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, London, Ont. Sept. 15-18, 2011.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same journal

"Highlights from JAAD International: Noninvasive imaging for basal cell carcinoma".

Journal of the American Academy of Dermatology·2026
Same journal

Effect of Primary Prophylaxis for Pneumocystis Pneumonia in Patients on Rituximab for Immune-Mediated Dermatologic Conditions: A Systematic Review and Meta-Analysis.

Journal of the American Academy of Dermatology·2026
Same journal

Dupilumab treatment improves linear growth and bone biomarkers in children with atopic dermatitis: Post hoc analysis of a phase 3 randomized, placebo-controlled clinical trial and an open-label extension study.

Journal of the American Academy of Dermatology·2026
Same journal

Real-World Effectiveness and Safety of Ritlecitinib in Adolescents with Severe Alopecia Areata: A 36-Week Single-Center Study.

Journal of the American Academy of Dermatology·2026
Same journal

Liquid Biopsy in Cutaneous Oncology: Current Practice and Future Directions.

Journal of the American Academy of Dermatology·2026
Same journal

Ethically protecting immunosuppressed patients in shared dermatology spaces.

Journal of the American Academy of Dermatology·2026
See all related articles

This study details the first case of localized acquired cutis laxa, a skin laxity condition. Neutrophils likely cause elastic fiber destruction, leading to this rare skin disorder.

Area of Science:

  • Dermatology
  • Pathology
  • Genetics

Background:

  • Acquired cutis laxa is a rare connective tissue disorder characterized by loose, sagging skin.
  • Localized forms are exceptionally uncommon, with limited understanding of underlying mechanisms.

Observation:

  • A patient presented with acral (extremities) skin laxity following digital swelling and papular urticaria.
  • Dapsone therapy successfully managed the swelling associated with the condition.

Findings:

  • Skin biopsies revealed fragmentation and near-complete loss of elastic fibers in affected areas.
  • Electron microscopy of urticarial lesions indicated neutrophilic dermatosis, with neutrophils interacting with elastic fibers.
  • Unaffected skin showed normal elastic fiber structure, suggesting a secondary degenerative process.

Related Experiment Videos

Implications:

  • The findings suggest that cutis laxa in this case is not due to a primary defect in elastic fibers.
  • Neutrophilic inflammation appears to play a crucial role in the destruction of elastic fibers, leading to acquired cutis laxa.
  • This case highlights a novel mechanism for the development of localized acquired cutis laxa, potentially involving immune-mediated damage.