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Published on: December 11, 2016
DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs
Liang Cheng1, Yue Jiang2, Zhenzhen Wang1
1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, PR China.
Abstract:
The similarity of pair-wise diseases reveals the molecular relationships between them. For example, similar diseases have the potential to be treated by common therapeutic chemicals (TCs). In this paper, we introduced DisSim, an online system for exploring similar diseases, and comparing corresponding TCs. Currently, DisSim implemented five state-of-the-art methods to measure the similarity between Disease Ontology (DO) terms and provide the significance of the similarity score. Furthermore, DisSim integrated TCs of diseases from the Comparative Toxicogenomics Database (CTD), which can help to identify potential relationships between TCs and similar diseases. The system can be accessed from http://123.59.132.21:8080/DisSim.
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