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Ibuprofen in paediatrics: pharmacology, prescribing and controversies

Camilla Moriarty1, Will Carroll2

  • 1Department of Paediatric, Chelsea and Westminster Hospital, London, UK.

Archives of Disease in Childhood. Education and Practice Edition
|July 27, 2016
PubMed

Insights

Ibuprofen is a common non-steroidal anti-inflammatory drug for children, but its use for fever is debated. Combined use with paracetamol is generally not recommended.

Area of Science:

  • Pharmacology
  • Pediatric Medicine
  • Drug Safety

Background:

  • Ibuprofen, a propionic acid derivative, is a widely used non-steroidal anti-inflammatory drug (NSAID) in pediatric practice.
  • It is one of the most frequently prescribed medications for children in hospital settings, second only to paracetamol.
  • The use of antipyretics like ibuprofen for treating fever in children is a subject of ongoing debate.

Purpose of the Study:

  • To detail the indications and mechanism of action for ibuprofen in pediatric care.
  • To provide an overview of ibuprofen's pharmacokinetic properties.
  • To emphasize key clinical practice messages regarding ibuprofen use in children.

Main Methods:

  • Literature review of ibuprofen's pharmacological and clinical data.
  • Analysis of current guidelines and controversies in pediatric fever management.
  • Pharmacokinetic profiling of oral ibuprofen formulations.

Main Results:

  • Fever is a natural response to infection and may not require routine treatment unless the child is symptomatic or distressed.
  • Combined treatment with paracetamol and ibuprofen is common but likely offers no additional benefit.
  • Understanding ibuprofen's indications, action, and pharmacokinetics is crucial for appropriate clinical use.

Conclusions:

  • Ibuprofen is a significant NSAID in pediatrics, but its use for fever requires careful consideration.
  • Routine treatment of fever with ibuprofen, especially in combination with paracetamol, is questionable.
  • This article provides essential information for optimizing ibuprofen's clinical application in children.

Keywords:
biologychildhoodibuprofenpharmacokinetics

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