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Updated: Mar 17, 2026

Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans
Guan-Yu Lin1, Hsueh-Fen Chen1, Yao-Peng Xue2
1Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, Taiwan.
Abstract:
Two antimicrobial P-113 peptide derivatives, P-113Du and P-113Tri, were investigated in this study. Notably, P-113Du and P-113Tri contained significant fractions of α-helix conformation and were less sensitive to high salt and low pH than P-113. Moreover, compared to P-113, these peptides exhibited increased antifungal activity against planktonic cells, biofilm cells, and clinical isolates of Candida albicans and non-albicans Candida spp. These results suggest that P-113Du and P-113Tri are promising candidates for development as novel antifungal agents.
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